MicrobiomeX® is a natural extract from citrus fruit designed to beneficially modulate the microbiome composition in the gut. It’s a first-in-class Flavobiotic® that protects the gut barrier and directly leverages the gut microbiome’s potential. This results in enhanced immune health, as well as anti-inflammatory effects.

Flavobiotic® for intestinal health

What is a Flavobiotic®? MicrobiomeX® consists of specific flavonoids that provide a unique dual effect on gut health. MicrobiomeX® has a direct effect through active metabolites and an indirect anti-inflammatory effect on the gut. A positive shift in the gut microbiome leads to a beneficial short-chain fatty acid (SCFA) profile which improves gut barrier function and enhances the immunity in the gut.

Superior stability

Superior Stability

Low daily dose

Low Daily Dose

Enhances microbiome composition

Enhances Microbiome Composition

Active flavonoids released in the gut

Active Flavonoids Released in the Gut

Clinicaly proven

Clinically Proven

Category Prebiotic

Clinically proven benefits

The health benefits of MicrobiomeX® have been assessed in two randomised double-blind clinical studies, which demonstrated its beneficial effect on the gut and immune health.

Gut microbiome modulation

Clinical research has shown that daily consumption of 500mg of MicrobiomeX® beneficially modulates the gut microbiota. The growth of specific bacterial groups, namely Clostridium cluster XIVa is promoted and particularly the species belonging to the genus Roseburia spp, which are well-known for their butyrate-producing property and many beneficial health effects.


Short-chain fatty acid profile

After 12 weeks of 500mg MicrobiomeX® consumption, a significant increase in the butyrate proportion of the total SCFA was observed. Furthermore, the butyrate over acetate ratio significantly increased in the MicrobiomeX® group compared to the placebo group. Butyrate has health-promoting effects such as positively affecting gut barrier function and lowering gut inflammation.

Gut inflammation & immune health

After 12 weeks of daily supplementation with 500mg of MicrobiomeX®, a strong reduction in faecal calprotectin was shown compared to the placebo group. Calprotectin is an important biomarker of gut inflammation, and its reduction suggests a decrease in pathogen load in the gut.

Additionally, recent clinical evidence demonstrated that MicrobiomeX® significantly increases the secretion of antibodies (IgA) in the gut lumen, indicating better protection against colonization by pathogens and viruses.


Mode of action

MicrobiomeX® has the unique quality of being effective two ways, directly through its active metabolites and indirectly through a shift in the gut microbiome composition.

Mode of action

Active metabolites

The flavonoids composing MicrobiomeX® are released after MicrobiomeX® is metabolized, and directly effect the gut barrier through protection from Reactive Oxygen Species.

Active metabolites

Microbiome shift

  • Improvement of gut barrier function by increaing short chain fatty acid production, which are an energy source for epithelial cells in the gut
  • Anti-oxidant effects, by increasing glutathione and decreasing Reactive Oxygen Species
  • Anti-inflammatory effect through interaction with immune cells (e.g. inhibition of NF-κB and ↓calprotecin levels)

White paper

Download the white paper and discover the scientific evidence around MicrobiomeX®.


Researched & developed by BioActor

MicrobiomeX® was researched and developed by BioActor, a Dutch life science company that develops health ingredients for functional foods, clinical nutrition, and dietary supplements.

Embedded in the Maastricht Health Campus, BioActor focuses on the core mission of bringing nutrition backed up by real science to consumers, helping them perform better and improve their health and well-being.

Find out more about BioActor, visit the website

Find out more about the sustainable way we use immature oranges for our citrus extracts