MicrobiomeX® is a natural extract from citrus fruit especially designed to change the microbiome composition in the gut. It’s a first-in-class Flavobiotic® that protects the gut barrier and directly leverages the gut microbiome’s potential. This results in enhanced gut and host health through anti-inflammatory effects.

Flavobiotic® for digestive health

What is a Flavobiotic®? MicrobiomeX® consists of specific flavonoids that provide a unique dual effect on gut health. MicrobiomeX® has a direct effect through active metabolites and an indirect anti-inflammatory effect on the gut. A positive shift in the gut microbiome leads to a beneficial short-chain fatty acid (SCFA) profile which improves gut barrier function and enhances the immunity in the gut.

Superior stability

Superior Stability

Low daily dose

Low Daily Dose

Enhances microbiome composition

Enhances Microbiome Composition

Active flavonoids released in the gut

Active flavonoids released in the gut

Clinicaly proven

Clinically Proven

Clinically proven

The benefits of MicrobiomeX® have been assessed in two studies, an in vitro study and an in vivo clinical study, which demonstrated its immune enhancing effects on the gut.

Enhances immunity in the gut

In vitro studies on MicrobiomeX® have shown that consumption can significantly modulate the gut microbiota, influencing the growth of specific bacterial groups, namely Clostridium cluster XIVa, capable of producing health benefits through SCFA production (e.g. butyrate).

A 12-week randomized, parallel, double-blind, placebo-controlled study was designed to examine the effects of a daily dose of 500mg of MicrobiomeX® on gut microbiome composition and calprotectin levels. MicrobiomeX® showed to lead to a significant shift in the SCFA profile and to lower calprotectin levels, suggesting a decreased pathogen load.

SCFA ratio daily intake microbiomex

*Significant effect on SCFA ratio after daily intake of MicrobiomeX®

Short-chain fatty acids

After 12 weeks intervention a strong increase of the Clostridium cluster XIVa was observed in the MicrobiomeX® group compared to the placebo group. This is also reflected by a significant increase in the butyrate proportion of the total SCFA. Furthermore, the butyrate over acetate ratio significantly increased in the MicrobiomeX® group as compared to the placebo group. Butyrate has health-promoting effects such as positively affecting gut barrier function and lowering gut inflammation.

Callprotectin levels

After 12 weeks of daily supplementation with MicrobiomeX®, a strong reduction in faecal calprotectin was shown as compared to the placebo group. This reduction suggests a reduction in pathogen load in the gut.

Mode of action

MicrobiomeX® has the unique quality of being effective two ways, directly through its active metabolites and indirectly through a shift in the gut microbiome composition.

Mode of action

Active metabolites

The flavonoids composing MicrobiomeX® are released after MicrobiomeX® is metabolized, and directly effect the gut barrier through protection from Reactive Oxygen Species.

Active metabolites

Microbiome shift

  • Improvement of gut barrier function, they are an energy source for epithelial cells in the gut
  • Anti-oxidant effects, by increasing Glutathione and decreasing Reactive Oxygen Species
  • Anti-inflammatory effect through interaction with immune cells (e.g. inhibition of NF-κB and ↓calprotecin levels